Cat#：203P11
序列（三字母）：Mca-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Arg-Lys(Dnp)-Arg-Arg-NH₂ trifluoroacetate salt
序列（单字母）：Mca-SEVNLDAEFRK(Dnp)-RR-NH₂
类似名：Mca-(Asn⁶⁷⁰,Leu⁶⁷¹)-APP₇₇₀ (667-676)-Lys(Dnp)-Arg-Arg amide
分子式：C₈₆H₁₂₅N₂₇O₂₉
分子量：2001.1
CAS#：438625-61-7
合成方法：Synthetic
存储条件：-20 ± 5 °C
应用：Alzheimer´s Disease
描述：This fluorescent (FRET) peptide substrate contains the ´Swedish´ Lys-Met/Asn-Leu mutation of the amyloid precursor protein (APP) β-secretase cleavage site. Mca-SEVNLDAEFRK(Dnp)RR-amide has been used for assaying β-secretase-like activity of thimet oligopeptidase (TOP, EC 3.4.24.15). The results suggested that TOP is a potential β-secretase candidate and is involved in the processing of APP in vivo.