Cat#：203P14
序列（三字母）：Abz-Val-Asn-Leu-Asp-Ala-Glu-EDDnp trifluoroacetate salt
序列（单字母）：Abz-VNLDAE-EDDnp
类似名：JMV2236, Abz-(Asn⁶⁷⁰,Leu⁶⁷¹)-APP₇₇₀ (669-674)-EDDnp
分子式：C₄₂H₅₈N₁₂O₁₆
分子量：986.99
CAS#：1007306-20-8
合成方法：Synthetic
存储条件：-20 ± 5 °C
应用：Alzheimer´s Disease
描述：Intramolecularly quenched fluorescent substrate containing the ortho-aminobenzoyl (Abz) / N-(2,4-dinitrophenyl)ethylenediamine (EDDnp) groups as the donor / acceptor pair. It corresponds to the Swedish-mutated (JMV2236) β-amyloid precursor protein (βAPP) sequence targeted by β-secretase BACE (β-site APP-cleaving activity). This FRET substrate is more selectively cleaved by BACE1 and BACE2 than by cathepsin D, a disintegrin and metalloprotease 10 (ADAM10), tumor necrosis α-converting enzyme (TACE), presenilin-1 (PS1), or presenilin-2 (PS2).