Cat#：217P421
序列（三字母）：H-Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu-OH trifluoroacetate salt
序列（单字母）：MAGPHPVIVITGPHEE
分子式：C₇₅H₁₁₈N₂₀O₂₂S
分子量：1683.95
CAS#：249537-73-3
合成方法：Synthetic
存储条件：-20 ± 5 °C
描述：The flow of information from calcium-mobilizing receptors to nuclear factor of activated T cells (NFAT)-dependent genes is critically dependent on interaction between the phosphatase calcineurin and the transcription factor NFAT. The high-affinity calcineurin-binding peptide potently inhibited NFAT activation and NFAT-dependent expression of endogenous cytokine genes in T cells, without affecting the expression of other cytokines that require calcineurin but not NFAT. NFAT inhibitors may be useful in treating chronic ailments such as myocardial hypertrophy, allergy, arthritis, and autoimmune disease.