Cat#: 112P26
序列（三字母）：H-Lys-Thr-Lys-Cys-Lys-Phe-Leu-Lys-Lys-Cys-OH (Disulfide bond)
序列（单字母）：KTKCKFLKKC
类似名：K-T-K-C-K-F-L-K-K-C
分子式：C₅₅H₉₇N₁₅O₁₂S₂
分子量：1224.6
CAS#：147396-10-9
合成方法：固相合成
存储条件：-20 ± 5 °C，避光，干燥
应用：Antimicrobial & Antiviral Peptides| Immunomodulating Agents
描述：The cyclic peptide KTKCKFLKKC has ben shown to form a strong complex with lipid A, the toxic component of the endotoxin lipopolysaccharide (LPS) with Ka = 0.56 · 10⁷ M⁻¹. It detoxifies LPS in vitro and prevents LPS-induced cytokine release and lethality in vivo. Furthermore, it shows neither antibiotic activity nor toxicity and might therefore be useful in the prophylaxis and treatment of LPS-mediated diseases. KTKCKFLKKC bears a structural resemblance to the peptide antibiotic and endotoxin inhibitor polymyxin B. It could be of use as an adjuvant for antibiotic therapy.