Cat#: 112P37
序列（三字母）：H-Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser-OH
序列（单字母）：LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES
类似名：Antibacterial Protein LL-37 (human), LL37, CAMP
分子式：C₂₀₅H₃₄₀N₆₀O₅₃
分子量：4493.33
CAS#：154947-66-7
合成方法：固相合成
存储条件：-20 ± 5 °C，避光，干燥
应用：Angiogenesis| Antimicrobial & Antiviral Peptides| Cancer Research| Inflammation Research
描述：LL-37 is an antimicrobial peptide with angiogenic activity. It corresponds to the C-terminal sequence (134-170) of the human cathelicidin antimicrobial protein hCAP18/LL-37 and is extracellularly released from hCAP18/LL-37 by proteolytic processing. hCAP18/LL-37 is an effector of the innate immune system and is expressed in leukocytes and epithelial cells where it is upregulated in association with inflammation and injury. An overexpression of hCAP18/LL-37 in a series of breast carcinomas could be demonstrated. LL-37 has been suggested to stimulate epithelial cell proliferation partially through formyl peptide receptor-like 1 (FPRL1) since blocking the receptor with pertussis toxin decreased the proliferative effect of LL-37 by approximately 50 %.