Cat#: 121P31
序列（三字母）：H-Leu-Asn-Lys-Asn-Pro-Ser(PO₃H₂)-Leu-Arg-Pro-Ser-Ala-Ile-Glu-Ile-Leu-Cys-OH trifluoroacetate salt
序列（单字母）：LNKNP(p)SLRPSAIEILC
分子式：C₇₇H₁₃₅N₂₂O₂₆PS
分子量：1848.09
合成方法：Synthetic
存储条件：-20 ± 5 °C
应用：Cancer Research
描述：Depletion of NEK11 prevents proteasome-dependent degradation of CDC25A, both in unperturbed and DNA-damaged cells. In addition, NEK11 directly phosphorylates CDC25A, and CHK1 (checkpoint kinase 1) directly activates NEK11 by phosphorylating it on Ser²⁷³. Taken together, NEK11 is an important component of the pathway enforcing the G2/M checkpoint, and genetic mutations in NEK11 may contribute to the development of cancer. These results have been shown by Melixetian and coworkers.