Cat#: 121P35
序列（三字母）：H-Ala-Val-Pro-Ile-Ala-Gln-Lys-OH trifluoroacetate salt
序列（单字母）：AVPIAQK
类似名：Mitochondrial Diablo Homolog (1-7) (human, mouse), Second Mitochondria-derived Activator of Caspase (1-7) (human, mouse), Smac Protein (1-7) (human, mouse)
分子式：C₃₃H₅₉N₉O₉
分子量：725.89
CAS#：401913-57-3
合成方法：Synthetic
存储条件：-20 ± 5 °C
应用：Apoptosis & Necrosis| Cancer Research
描述：Smac-N7 Peptide corresponds to the N-terminal seven residues of Smac (second mitochondria-derived activator of caspase) also known as DIABLO. Smac/DIABLO is a mitochondrial proapoptotic protein that activates caspases in the cytochrome c/Apaf-1/caspase-9 pathway by neutralizing inhibitor of apoptosis protein (IAP). Smac-N7 peptide promoted procaspase-3 activation in vitro at around 10 µM and inhibited binding of caspase-9-p12 to the BIR3 (baculoviral IAP repeat 3) domain of XIAP (X-linked IAP). The finding that Smac/DIABLO agonists could enhance the apoptosis-inducing potential of irradiation and chemotherapeutic drugs might lead to promising new candidates for cancer treatment.