Cat#: 121P40
序列（三字母）：H-Cys-Asn-Gly-Arg-Cys-Gly-Gly-D-Lys-D-Leu-D-Ala-D-Lys-D-Leu-D-Ala-D-Lys-D-Lys-D-Leu-D-Ala-D-Lys-D-Leu-D-Ala-D-Lys-NH₂ trifluoroacetate salt(Disulfide bond)
序列（单字母）：CNGRCGGklaklakklaklak-NH₂
类似名：CNGRC-GG-(klaklak)₂-NH₂ (Disulfide bond)
分子式：C₉₄H₁₇₄N₃₂O₂₂S₂
分子量：2168.75
CAS#：1926163-30-5
合成方法：Synthetic
存储条件：-20 ± 5 °C
应用：Apoptosis & Necrosis| Cancer Research
描述：Tumor targeted pro-apoptotic peptide consists of two functional domains, on the one hand a "homing" or targeting domain, which guides the peptide to targeted cells and allows its internalization and on the other hand a programmed cell death-inducing sequence. The targeting domain contains the Asn-Gly-Arg (NGR) motif which has proven useful for delivering various anti-tumor compounds and viral particles to tumor vessels. As programmed cell death-inducing sequence the synthetic 14 amino acid peptide klaklakklaklak, also called (klaklak)₂, was selected, because it kills bacteria at concentrations 1% of those required to kill eukaryotic cells. This pro-apoptotic domain is non-toxic outside of cells, but toxic when internalized into targeted cells by the disruption of mitochondrial membranes. Therefore, targeted pro-apoptotic peptides represent a potential new class of anti-cancer agents. They combine two levels of specificity: "homing" to targeted cells and selective apoptosis of such cells after entry.