Cat#：139P24
序列（三字母）：H-Cys-psi(CH₂NH)Val-psi(CH₂NH)Phe-Met-OH trifluoroacetate salt
序列（单字母）：C-psi(CH₂NH)Val-psi(CH₂NH)Phe-M
类似名：B581, Farnesyltransferase inhibitor, N-[(S)-2-((R)-2-Amino-3-mercapto-propylamino)-3-methyl-butyl]-Phe-Met-OH
分子式：C₂₂H₃₈N₄O₃S₂
分子量：470.7
CAS#：149759-96-6
合成方法：Synthetic
存储条件：-20 ± 5 °C
应用：Cancer Research
描述：B581, Cys-psi(CH₂NH)-Val- psi[CH₂NH]-Phe-Met is a farnesyltransferase (FTase) inhibitor of special stability and membrane permeability. Due to its high selectivity, B581 is more than 30-fold more active against FTase (IC₅₀ = 21 nM in vitro) than against geranylgeranyltransferase (GGTase). Inhibitors of the farnesyltransferase are potential candidates for the development of anticancer drugs.