Cat#：139P28
序列（三字母）：Decanoyl-Arg-Val-Lys-Arg-chloromethylketone trifluoroacetate salt
序列（单字母）：Decanoyl-RVKR-chloromethylketone
类似名：Furin Inhibitor I, Dec-RVKR-CMK, Furin Convertase Inhibitor (Chloromethylketone)
分子式：C₃₄H₆₆ClN₁₁O₅
分子量：744.42
CAS#：150113-99-8
合成方法：Synthetic
存储条件：-20 ± 5 °C
应用：Virology
描述：Dec-RVKR-CMK binds to the catalytic site of furin and therefore acts as a potent inhibitor of cleavage and fusion activity of viral glycoproteins, as well as virus replication. Furthermore it was demonstrated that Dec-RVKR-CMK decreased the production of β-amyloid-induced active matrix metalloproteinase 2 in U87 cells. Apart from furin, N-1505 also inhibited the proprotein convertases PC7/LPC, PACE4, and PC6 (W.Garten, personal communication).