Cat#：139P70
序列（三字母）：Z-Ile-Glu(OtBu)-Ala-Leu-aldehyde
序列（单字母）：Z-IE(OtBu)-AL-aldehyde
类似名：PSI, Proteasome Inhibitor I, Z-Ile-Glu(OtBu)-Ala-L-leucinal
分子式：C₃₂H₅₀N₄O₈
分子量：618.77
CAS#：158442-41-2
合成方法：Synthetic
存储条件：-20 ± 5 °C
应用：Apoptosis & Necrosis| Cosmetic Peptides & Dermatology
描述：Z-IE(OtBu)AL-CHO is an inhibitor of chymotrypsin-like activity of the multicatalytic proteinase complex (MPC; 20S proteasome) in HT4 cells. It is the first inhibitor reported so far which can cause accumulation of ubiquitinylated proteins in neuronal cells. Furthermore, this compound induced massive apoptosis in murine leukaemia L1210 cells. Therefore, proteasome inhibitors may be considered as potential anti-neoplastic agents.