Cat#：140P67
序列（三字母）：Boc-Arg-Val-Arg-Arg-AMC acetate salt
序列（单字母）：Boc-RVRR-AMC
分子式：C₃₈H₆₂N₁₄O₈
分子量：843.01
CAS#：136132-77-9
合成方法：Synthetic
存储条件：-20 ± 5 °C
描述：The fluorogenic substrate Boc-RVRR-AMC is efficiently cleaved by furin, a mammalian homolog of the yeast Kex2 endoprotease (kcat/Km approx. 4·10³ M⁻¹s⁻¹). As a calcium-dependent serine protease associated with Golgi membranes, furin is responsible for the secretory processing of precursor proteins at paired basic residues. Boc-RVRR-AMC is also cleaved by proprotein convertase 4. Stock solutions of Boc-RVRR-AMC are best prepared in DMSO.