Cat#：143P24
序列（三字母）：Cyclo(-Arg-Gly-Asp-D-Phe-Val) trifluoroacetate salt
序列（单字母）：c(RGDfV)
类似名：EMD 66203, c(RGDfV), c(Arg-Gly-Asp-DPhe-Val)
分子式：C₂₆H₃₈N₈O₇
分子量：574.64
CAS#：137813-35-5
合成方法：Synthetic
存储条件：-20 ± 5 °C
应用：Adhesion Molecules & Extracellular Matrix Proteins| Cancer Research| Regenerative Medicine
描述：c(RGDfV) is a potent inhibitor of cell adhesion. It inhibited tumor cell adhesion to laminin and vitronectin substrates. In vivo investigations in rats provided the first evidence of its utility in the amelioration of ischemic acute renal failure. c(RGDfV) inhibited tubular obstruction by preventing cell-cell adhesion. Hammes et al. showed that the cyclopeptide can also be used to prevent retinal neovascularization. c(RGDfV) binds to αvβ3 receptors.