Cat#：146P09
序列（三字母）：H-Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Pro-Pro-Ala-Leu-Ala-Leu-Ala-NH₂
序列（单字母）：GWTLNSAGYLLGPPPALALA-NH₂
类似名：M40
分子式：C₉₄H₁₄₅N₂₃O₂₄
分子量：1981.33
CAS#：143896-17-7
合成方法：Synthetic
存储条件：-20 ± 5 °C
应用：Alzheimer´s Disease| Obesity Research
描述：M40, a peptide containing the N-terminal galanin sequence (1-13), is an antagonist of the galanin receptor. M40 significantly antagonized galanin-induced feeding behavior at doses approximately equimolar to the active doses of rat galanin. M40 inhibited the binding of (¹²⁵I-Tyr²⁶)-galanin (porcine) in rat hypothalamic membranes with an IC₅₀ value of 15 nM. Coadministration of M40 with a muscarinic M1 agonist may enhance the efficacy of cholinergic treatments for the cognitive deficits of Alzheimer disease.