Cat#：153P02
序列（三字母）：H-His-Asp-Glu-Phe-Glu-Arg-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-Gly-OH trifluoroacetate salt
序列（单字母）：HDEFERHAEGTFTSDVSSYLEGQAAKEFIAWLVKGRG
类似名：Glucagon-Like Peptide 1 (1-37) (human, bovine, guinea pig, mouse, rat), Proglucagon (72-108) (human, bovine, guinea pig, mouse, rat), Preproglucagon (92-128) (human, bovine, guinea pig, mouse, rat)
分子式：C₁₈₆H₂₇₅N₅₁O₅₉
分子量：4169.54
CAS#：87805-34-3
合成方法：Synthetic
存储条件：-20 ± 5 °C
应用：Diabetes
描述：Glucagon-Like Peptide 1 (GLP-1) is synthesized by posttranslational processing of proglucagon in the intestine and pancreas and plays an important role in metabolic homeostasis. Among the different molecular forms, such as GLP-1 (7-36) amide and GLP-1 (7-37), the function of GLP-1 (1-37) has been unclear. GLP-1 (1-37) was shown to convert intestinal epithelial cells into insulin-producing cells. These observations turned GLP-1 (1-37) into a new promising therapeutic compound for the treatment of diabetes mellitus. In animal models of dilated cardiomyopathy, hypertensive heart failure, and myocardial infarction, GLP-1 has shown a remarkable cardioprotective activity.