Cat#：162P12
序列（三字母）：H-His-Cys-Lys-Phe-Trp-Trp-OH
序列（单字母）：HCKFWW
分子式：C₄₆H₅₅N₁₁O₇S
分子量：906.08
CAS#：172546-75-7
合成方法：Synthetic
存储条件：-20 ± 5 °C
应用：Infectious Disease| Virology
描述：HCKFWW, potent inhibitor of the HIV-encoded integrase (IN), the enzyme responsible for the integration of HIV DNA into the human genome. HCKFWW inhibits IN-mediated 3´processing and integration with an IC₅₀ of 2 µM. The peptide is also active on IN proteins from other retroviruses such as HIV-2, feline immunodeficiency virus and Moloney murine leukemia virus. It was also found to inhibit the disintegration reaction, suggesting that this hexapeptide acts at or near the catalytic site of IN.