Cat#：173P01
序列（三字母）：4-Abz-Gly-Pro-D-Leu-D-Ala-NHOH trifluoroacetate salt
序列（单字母）：PABA-GPla-NHOH
类似名：FN-439, MMP Inhibitor 1
分子式：C₂₃H₃₄N₆O₆
分子量：490.56
CAS#：124168-73-6
合成方法：Synthetic
存储条件：-20 ± 5 °C
应用：Cancer Research| Inflammation Research
描述：The water-soluble peptidylhydroxamic acid FN439 is a broad-spectrum inhibitor of human matrix metalloproteinases. 4-Abz-Gly-Pro-D-Leu-D-Ala-NHOH retains its activity even after prolonged incubation with pronase or human granulocyte elastase. FN 439 inhibits interstitial and granulocyte collagenases, granulocyte gelatinase and skin fibroblast stromelysin with IC₅₀ of 1 · 10⁻⁶ M, 3 · 10⁻⁵ M and 1.5 · 10⁻⁴ M, respectively.