Cat#：181P01
序列（三字母）：Diphenylacetyl-D-Arg-4-hydroxybenzylamide trifluoroacetate salt
序列（单字母）：Diphenylacetyl-r-4-hydroxybenzylamide
类似名：BIBP 3226
分子式：C₂₇H₃₁N₅O₃
分子量：473.58
CAS#：159013-54-4
合成方法：Synthetic
存储条件：-20 ± 5 °C
应用：Cardiovascular System & Diseases| Obesity Research
描述：The Y₁ receptor antagonist BIBP-3226, a derivative of D-arginine, binds to the Y₁ receptor with high affinity (its Ki was 7 nM versus the Ki of 0.2 nM for NPY). BIBP3226 also reduced the NPY-induced increase in intracellular calcium as well as the pressor response in vitro and in vivo. BIBP3226 inhibited NPY induced feeding in rats. In dogs, intra-arterial infusion of BIBP-3226 interrupted tonic NPY Y1 receptor-mediated vasoconstriction in exercising skeletal muscle, resulting in substantial increases in experimental limb blood flow. CAS-Number (trifluoroacetate): 1068148-47-9.