Cat#：187P02
序列（三字母）：Pyr-Pro-Leu-Pro-Asp-Cys-Cys-Arg-Gln-Lys-Thr-Cys-Ser-Cys-Arg-Leu-Tyr-Glu-Leu-Leu-His-Gly-Ala-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Leu-NH₂ trifluoroacetate salt(Disulfide bonds between Cys⁶ and Cys¹²/Cys⁷ and Cys¹⁴)
序列（单字母）：pEPLPDCCRQKTCSCRLYELLHGAGNHAAGILTL-NH₂
类似名：Hypocretin-1 (human, mouse, rat), Orexin A, human, bovine, rat, mouse
分子式：C₁₅₂H₂₄₃N₄₇O₄₄S₄
分子量：3561.16
CAS#：205640-90-0
合成方法：Synthetic
存储条件：-20 ± 5 °C
应用：Obesity Research| Parkinson’s Disease
描述：Orexin A (OXA, hypocretin-1) is a hypothalamic neuropeptide regulating the feeding behavior. Central administration of orexin A to rats stimulated food consumption in a dose-dependent manner. The effect persisted at 4 h after injection, as orexin A seems to be resistant to peptidases. Orexin A specifically binds a G protein-coupled receptor, OX₁R (IC₅₀ = 20 nM to displace 50 % of radiolabeled orexin A bound to this receptor). Orexin A produced in the amygdala induces wakefulness and plays a role in the induction of human emotions. Narcolepsy has been associated with orexin deficiency.