Cat#: 103P10
序列（三字母）：H-Ala-Arg-Leu-Asp-Val-Ala-Ser-Glu-Phe-Arg-Lys-Lys-Trp-Asn-Lys-Trp-Ala-Leu-Ser-Arg-NH₂
序列（单字母）：ARLDVASEFRKKWNKWALSR-NH₂
类似名：PAMP, Pro-Adrenomedullin N-20, human
分子式：C₁₁₂H₁₇₈N₃₆O₂₇
分子量：2460.87
CAS#：150238-87-2
合成方法：固相合成
存储条件：-20 ± 5 °C，避光，干燥
应用：Cardiovascular System & Diseases
描述：Proadrenomedullin, the precursor of adrenomedullin, contains a unique 20-residue sequence termed proadrenomedullin NH₂-terminal 20 peptide (PAMP). The i.v. administration of PAMP produces a rapid and strong hypotensive effect in anesthetized rats. It has been suggested, that PAMP functions as an inhibitory modulator of renal noradrenergic neurotransmission and plays an important role in regulating renal functions. Furthermore, it has been suggested that PAMP can act as an inhibitory regulator of adrenal catecholamine release in vivo and has a potent hyperglycemic effect after intra-third cerebroventricular administration in fasted mice.