产品详情
Cat#:181P29
序列(三字母):H-Gly-Pro-Ser-Gln-Pro-Thr-Tyr-Pro-Gly-Asp-Asn-Ala-Thr-Pro-Glu-Gln-Met-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-Arg-Tyr-Ile-Asn-Met-Ala-Aib-Arg-Gln-Arg-Tyr-NH₂ trifluoroacetate salt
序列(单字母):GPSQPTYPGDNATPEQMARYYSALRRYINMA-Aib-YQYR-NH₂
类似名:(Gly¹,Gln⁴·¹⁶,Thr⁶·¹³,Tyr⁷,Asp¹⁰,Asn¹¹,Pro¹⁴,Arg²⁶,Met³⁰,Ala³¹,Aib³²)-Neuropeptide Y (human, rat)
分子式:C₁₈₃H₂₈₁N₅₇O₅₄S₂
分子量:4207.73
CAS#:313988-89-5
合成方法:Synthetic
存储条件:-20 ± 5 °C
应用:Obesity Research
描述:This (Ala-Aib)-containing pancreatic peptide/neuropeptide Y chimera is a highly selective neuropeptide Y₅ receptor agonist. At this receptor this compound turned out to be 25-fold more potent than the derivative H-5084 (0.24 nM vs 6 nM) and three-fold more potent than the native ligand neuropeptide Y (H-6375) (0.24 nM vs 0.6 nM). This analog turned out to increase feeding approximately 2.5-fold more effective than neuropeptide Y.
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