Cat#：183P12
序列（三字母）：H-Lys-psi(CH₂NH)Lys-Pro-Tyr-Ile-Leu-OH
序列（单字母）：K-psi(CH₂NH)KPYIL
类似名：JMV 449, (Lys8-acetyl-Lys9)-Neurotensin (8-13)
分子式：C₃₈H₆₆N₈O₇
分子量：746.99
CAS#：139026-66-7
合成方法：Synthetic
存储条件：-20 ± 5 °C
应用：Cancer Research
描述：Replacement of the Lys⁸-Lys⁹ peptide bond by the CH₂NH bond produced an analog with quite interesting pharmacological properties. The degradation-resistant peptide analog Lys-psi(CH2NH)Lys-Pro-Tyr-Ile-Leu (JMV-449) was the most active in the binding and biological assays. JMV-449 exhibited higher binding and biological potencies than neurotensin. JMV449 was also about 10 times more potent than neurotensin (8-13) in the bioassay, whereas both peptides were equipotent in the binding assay.