Cat#：203P16
序列（三字母）：3,5-Difluorophenylacetyl-Ala-Phg-OMe
序列（单字母）：3,5-Difluorophenylacetyl-A-Phg-OMe
类似名：DAPM
分子式：C₂₀H₂₀F₂N₂O₄
分子量：390.39
CAS#：208255-51-0
合成方法：Synthetic
存储条件：-20 ± 5 °C
应用：Alzheimer´s Disease
描述：DAPM, a cell-permeable γ-secretase inhibitor with anti-aggregation properties that dose-dependently inhibits amyloid β-protein (Aβ) secretion in 7PA2 Chinese hamster ovary (CHO) cells with an half-maximal inhibitory concentration of IC₅₀ ~ 10 nM. DAPM prevents oligomer formation by selectively blocking the Aβ dimer and trimer formation at doses that allow appreciable monomer production.