Cat#: 112P68
序列（三字母）：Cyclo(-Gly-Ile-Cys-Arg-Cys-Ile-Cys-Gly-Arg-Gly-Ile-Cys-Arg-Cys-Ile-Cys-Gly-Arg)(Disulfide bonds between Cys³ and Cys¹⁶/Cys⁵ and Cys¹⁴/Cys⁷ and Cys¹²)
序列（单字母）：Cyclo(-GICRCICGRGICRCICGR)
类似名：RC-100
分子式：C₇₄H₁₂₈N₃₀O₁₈S₆
分子量：1918.42
CAS#：724760-19-4
合成方法：固相合成
存储条件：-20 ± 5 °C，避光，干燥
应用：Antimicrobial & Antiviral Peptides| Infectious Disease
描述：The theta-defensin retrocyclin-1, also called RC-100, is a circular octadecapeptide containing an internal trisulfide ladder. Besides its antimicrobial activity, retrocyclin-1 has a remarkable ability to protect human cells in vitro from infection by T- and M-tropic strains of HIV-1. Its effectiveness against HIV-1 results from the prevention of viral entry, and is correlated with its ability to recognize and bind with high affinity to glycoproteins and glycolipids implicated in HIV-1 entry, such as gp120 (KD = 35.4 nM), CD4 (KD = 31 nM), and galactosylceramide (KD = 24.1 nM). Retrocyclin represents a new class of small molecule HIV-1 entry inhibitors.